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The drug interaction databases classify this as a moderate interaction, noting that "as you lose weight during treatment with phentermine, your dosage requirement of tirzepatide or any other diabetic medications may change." This is not a minor technicality

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Share your full supplement list with your clinician to avoid excessive dosing or unnecessary duplication

Neurons innervating the striatum, including dopaminergic neurons from the SNcVTA regions, take up AA, which, in low-TH-expressing cells, the phenotype can switch to a dopaminergic one through TH synthesis