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The mechanosensing gene PIEZO1 has been linked to joint mobility abnormalities [74], while novel mechanisms involving genes like ULK4 and KCNH1 suggest additional roles in tissue maintenance [74]

Fas and Fas Ligand Expression in Inflamed Islets in Pancreas Sections of Patients With Recent-Onset Type I Diabetes Mellitus

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Therefore, in clinical practice, healthcare providers may consider alternative treatment options or combination therapies if achieving optimal postprandial glucose control is a primary concern for individuals with T2DM