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Cold stress in mice has also been shown to change the composition of the gut microbiota, and fecal transplants from cold-stressed donors to room temperature-housed recipients elicit the same increases in intestinal morphology, independent of food intake 5,7

The peptide stimulates endogenous GH production rather than suppressing it, so the hypothalamic-pituitary axis is not shut down in the way it would be with exogenous hormone administration

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