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It is characterized by increased iron accumulation, leading to toxic ROS generation by the Fenton reaction ( Of note, LA has been reported to act as a direct free radical scavenger that alleviated oxidative stress ( in vivo and in vitro ( Several studies indicated that p53 activation was associated with the inhibition of system xCT ( via reducing ferroptosis ( Taken together, our study demonstrated that ferroptosis played an important role in AKI induced by FA overdose injection in mice, which could be alleviated by LA supplementation, indicating that LA may be used as a potential therapeutic approach to ameliorate AKI caused by drugs or toxicants in the clinic

Clinical trials demonstrate substantial reductions in waist circumference and visceral fat alongside total body weight loss

Alcohol is mainly absorbed in the small intestine

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