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pubmed.ncbi.nlm.nih.gov/30050888 Thomson RL, Spedding S, Buckley JD

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As part of this initiative, our team had the opportunity to support the study comprehensively across its full lifecyclereinforcing the value of rigorous late-phase research in real-world clinical environments

Our metabolomics data from RA patients with high ADA activity showed alterations in metabolites belonging to alanine aspartate and glutamate metabolism, arginine biosynthesis, citrate cycle (tricarboxylic acid (TCA) cycle), butanoate metabolism, starch and sucrose metabolism, and pyruvate metabolic pathways