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Evidence from Clinical Trials on Weight Loss and Body Composition Liraglutide-based clinical evidence from the SCALE (Satiety and Clinical Adiposity-Liraglutide Evidence) trials (NCT01272219 and NCT01272232), which included older adults within the adult study population, reported that a 56-week intervention with liraglutide 3 mg/day as an adjunct to lifestyle modification resulted in significant weight loss compared with placebo [41, 42]
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Studies indicate that intrahepatic triacylglycerol (TAG) content differs among populations, with lean individuals showing 11%, obese individuals 19%, and obese individuals with NAFLD up to 38%, largely due to elevated hepatic DNL [10, 60]
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