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Severely damaged red neurons, without any inflammatory reaction, were present in all animals, in more then one half of hippocampal neurons, neurons of the dentate nucleus, Purkinje cells and other cerebellar nuclei

Its relevance to women's health crystallised with the finding that MOTS-c levels decline with age and estrogen depletion correlating directly with reduced skeletal muscle insulin sensitivity and visceral adiposity in postmenopausal women

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Cardiac cells that have been genetically engineered to lack NRF2 have been shown to be unable to resist damage due to reactive oxygen radicals, presumably due to a deficiency of SOD (3)