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Across the cagrilintide clinical program, the dominant tolerability issues have been gastrointestinal: nausea, reduced appetite, constipation, and, less commonly, vomiting a profile shared with pramlintide and with GLP-1 agonists, and mechanistically expected from a compound that slows the stomach and engages the area postrema

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What sets GHK-Cu apart in the research literature is scale: naturally occurring levels of the peptide in human plasma decline from roughly 200 ng/mL at age 20 to about 80 ng/mL by age 60, a drop researchers have used as a starting point for studying its potential connection to age-related changes in tissue repair