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ROS play a crucial role in the pathogenesis of AD because, by reacting with all macromolecules (lipids, proteins, nucleic acids, and carbohydrates), they promote a chain reaction that leads to damage and cell death

PLoS One 11 (6), e0157509e0157514

The most recent and methodologically rigorous of them, restricted to four placebo-controlled trials in 667 patients, found no significant difference from placebo on MDS-UPDRS Part III in either the on- or off-medication state [7]

Novo has seen its market capitalization fall from more than $600 billion in 2024, when it was briefly the most valuable company in Europe, to about $227 billion