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The most significant published evidence to date comes from a phase 2 randomised controlled trial (Jastreboff et al., New England Journal of Medicine , 2023), which demonstrated substantial dose-dependent weight loss in adults with obesity over 24 weeks, with continued weight reduction observed at 48 weeks

This system regulates metabolism, slows gastric emptying, controls appetite, and stimulates insulin release in response to food intake

The other thing that we also talk about is that people (who) are obese already are prone to not being fit, he said

They like the vitality, they like the muscle growth, they like the fat loss