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I suspect this is from the glucagon agonism of the drug as glucagon stimulates the formation of extra bile acids/bile salts in the liver which can be very irritating to the intestinal lining causing diarrhea

doi: 10.3389/fendo.2026.1762596 Received 07 December 2025 Revised 21 February 2026 Accepted 02 March 2026 Published 16 March 2026 Volume 17 - 2026 Edited by Claire Joanne Stocker, Aston University, United Kingdom Reviewed by Damasia Becu-Villalobos, CONICET Institute of Biology and Experimental Medicine (IBYME), Argentina Edward Wargent, University of Buckingham, United Kingdom Dzilda Velickiene, Hospital of Lithuanian University of Health Sciences Kaunas Clinics, Lithuania Updates Copyright 2026 Wang, Luo, Fang, Ge, Huang and Deng

The orally disintegrating tablet formulation offers unique administration considerations that distinguish it from traditional oral medications or injectable GLP-1 receptor agonists

While oral supplementation is the most convenient, its also less effective due to glutathiones poor absorption in the digestive tract