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The new data reveal which the Danish pharma group said pointed to a "differentiated clinical profile" for the once-weekly injectable drug comes right after Novo Nordisk reported disappointing data with amylin and GLP-1-targeted CagriSema (cagrilintide and semaglutide)

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Mechanistically, this was associated with increased BrdU-positive neurons, preservation of dopaminergic neurons (via elevated tyrosine hydroxylase and dopamine transporter levels), enhanced antioxidant defenses (e.g., catalase, GPX1/2, HO-1), and upregulation of autophagy markers such as LC3-II and Beclin-1