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Healthy controls rear, raise their both forelimbs and grasp the forceps nose defensively

In the brain, NAD+ supports: ATP production (cellular energy) Neurotransmitter synthesis and regulation DNA repair and cellular recovery Overall neuronal efficiency As NAD+ levels declinedue to age, stress, poor sleep, alcohol use, or illnessthe brain becomes less efficient

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Our results also reveal mitochondrial iron overload via HO-1 mitochondrial translocation as a key mechanism as well as a potential molecular target for oxidative stress-induced ferroptosis in cardiomyocytes