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Because copper is a cofactor in vascular signaling pathways, GHK-Cu is also a common reference peptide in in-vitro angiogenesis assay models for repair-peptide research and in fibroblast proliferation and collagen-synthesis assays

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The brands Copper Amino Isolate Serum 3 1:1, abbreviated as CAIS3, is a product made almost entirely out of GHK-Cu

Additionally, it has been reported that OS affects epigenetic regulatory mechanisms involved in the regulation of pancreatic cell survival and insulin secretion, like DNA methylation, chromatin architectural modification, and non-coding RNA (Kowluru and Mishra, 2017)