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Patients with NASH have increased TNF levels in both the circulation and in hepatic tissues, which correlate with disease severity and mortality 21
There is no evidence to support that a wider margin is beneficial.[1] Evidence (excision): The Intergroup Melanoma Surgical Trial Task 2b compared 2-cm versus 4-cm margins for 740 patients with melanomas that were 1 mm to 4 mm thick.[2] With a median follow-up of more than 10 years, no significant difference in local recurrence or survival was observed between the two groups
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