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Moreover, compared to c[Glu 22 Lys 26 ] Gly 8 GLP-1, the affinity and activity of c[Asp 22 Lys 26 ] Gly 8 GLP-1 are lower while those of c[hGlu 22 Lys 26 ] Gly 8 GLP-1 are higher (hGlu: homoglutamic acid),36 indicating that the length of the amino acid side chain is an important factor

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In summary, while progress has been made through the efforts of key bodies such as EFSA, USFDA, and WHO in drafting comprehensive guidelines and risk assessment frameworks for food nanomaterials, navigating the regulatory landscape for nanoencapsulated nutraceuticals continues to be challenging, and the absence of uniform, mandatory global regulations must be addressed for these technologies to gain widespread acceptance