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This increased workload can lead to extreme exhaustion in the period immediately following the injection

However, as discussed elsewhere in this review, competition for L-arginine and L-ornithine substrates by synthetic enzymes is often rate-limiting in the synthesis of nitrergic co-transmitters (Figure 1), and the absolute level of available Put in the brain is generally fairly low (Malik et al., 2020

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Tralokinumab-ldrm and nemolizumab can cause other side effects like upper respiratory tract infections (such as the common cold) and high levels of eosinophils (a type of white blood cell)