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Through the above measures, the stability and effectiveness of GHK-Cu in skin care products can be ensured to the greatest extent, thereby exerting its anti-aging and repairing effects

However, exposure to high glucose conditions did increase mRNA expression and membrane-bound DPP-4 activity in human glomerular (76) and dermal (77) microvascular endothelial cells in vitro , although, interestingly, not in macrovascular (human aortic) endothelial cells (77)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Hensley C.T., Wasti A.T., DeBerardinis R.J