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After ingestion, folate from food is hydrolyzed in the gut, where it is converted first to tetrahydrofolate by the enzyme dihydrofolate reductase and then to the active form 5-MTHF, by the enzyme MTHFR

postulated the role of indoxyl sulfate in the pathogenesis of renal anemia: indoxyl sulfate could stimulate oxidative stress and induce eryptosis through Organic Anion Transporter 2 (OAT2)- and NADPH oxidase-dependent, as well as GSH-independent mechanisms [257]