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Effect of Phentermine/Topiramate on the Pharmacokinetics of Co-administered Drugs * A single study examined the effect of multiple-dose phentermine and topiramate extended-release 15 mg/92 mg once daily on the pharmacokinetics of multiple-dose 500 mg metformin twice daily and multiple-dose 100 mg sitagliptin once daily in 10 males and 10 females (mean BMI of 27.1 kg/m2 and range of 22.2 to 32.7 kg/m2)

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But there is a risk that people start seeing this drug as a quick weight-loss strategy, Rubino said

The pineal gland contributes to circadian timing through the synthesis and release of melatonin