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According to the Randle hypothesis the fatty acid-induced insulin resistance will result in elevated intracellular levels of both glucose and glucose-6-phosphate (Figure 7)

21 In addition, there were also increased levels of proinflammatory cytokines, such as IL-1, TNF-, and IL-17, which correlated with an increased production of free radicals

"Collar of Venus" wrinkles can be reduced and neck skin presenting elastosis can be rejuvenated by means of intradermal cellular Adipofilling

Together, these data suggest potentially distinct cellular/molecular effects of BPA depending on exposure age, concentration, and cell type