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What Causes Rebound Weight Gain After Stopping Semaglutide, Liraglutide, and Other Weight Loss Injections and How to Maintain Results Long-Term Medically reviewed by Dr Jeff Khoo, Medical Director, Revix Clinic Quick answer: Weight often returns after stopping GLP-1 injections (such as semaglutide or liraglutide) because these medications suppress appetite and slow gastric emptying while you take them but they do not change the underlying metabolic, hormonal, and inflammatory drivers that caused the weight gain