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Additionally, CAFs are capable of breaking down the ECM through the release of matrix metalloproteinases (MMPs) and the creation of novel matrix proteins involved in tumor penetration and angiogenesis [51,52,53]

There is a theoretical concern, supported by some biological evidence, that elevated IGF-1 activity in a patient with occult or a history of certain hormone-sensitive cancers could be problematic

Pilot studies of low-intensity vibration show that it may reduce symptoms and improve physical function in cancer survivors, but larger trials are needed to confirm these benefits (Krasnow et al., 2025

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