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From the recent investigations done, it was reported that 75% of GLP-1 metabolism by DPP-IV and elimination occurs in the gut and liver, respectively, permitting only 1015% of GLP-1 circulation in the blood ( Figure 2 Status of the naturally available DPP-IV inhibitors Various naturally available plant-based compounds are investigated as DPP-IV inhibitors

Randomized controlled trials have demonstrated that supplementation with B vitamins, including vitamin B 6 , effectively reduces blood concentrations of homocysteine

J Enzy Inhibit Med Chem (2009) 24:10616

Prescriptions are issued only after a thorough medical evaluation