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The distinction sounds academic until you consider what it means for appetite suppression, muscle preservation, metabolic adaptation, and long-term outcomes

Polycythemia or hematocrit consistently above 54% may contraindicate TRT initiation until addressed

NAD+, MOTS-c, Sermorelin, CJC-1295, Ipamorelin, and other peptides are often used in longevity-focused protocols, although many still lack strong long-term human data and should be used only with medical supervision and realistic expectations

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