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2-adrenergic agonists such as terbutaline, or related pharmacological interventions, can modulate Arg metabolism-related processes and shift the polarization balance by affecting pathways such as high-mobility group box 1 (HMGB1) and nuclear factor-B (NF-B)

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Analytical verification requires reverse-phase HPLC with UV detection at 214-220 nm to confirm retention time consistency and peak purity above 95%, while mass spectrometry (MALDI-TOF or ESI-MS) can confirm the expected molecular ion at 1419.53 Da and identify any truncation or oxidation products