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doi: 10.1111/pcn.12362 49

Bottom right, ratio of ExP5 efficacy (calculated using the Ehlert method 44 ) relative to GLP-1 in cAMP and -arrestin1 recruitment confirms that ExP5 bias arises from enhanced G s efficacy

For example, GLP-1R agonism appears to facilitate new learning, potentially by modifying neural circuits involved in reward and adaptive behavior (Hanssen et al., 2023)