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At the GIPR, tirzepatide triggers Gs-mediated cAMP production in adipocytes and pancreatic beta cells, enhancing insulin secretion, improving fat storage efficiency in subcutaneous depots, and increasing lipid buffering capacity

Titration Start tirzepatide alone for 8 weeks, then add cagrilintide at 0.25 mg/week

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In a 68-week clinical study of Wegovy, about 1 in 3 adults with obesity or with overweight and weight-related medical problems achieved 20% weight loss