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This review was based on the international glucagon conference, entitled A hundred years with glucagon and a hundred more, held in Copenhagen, Denmark, in November 2022

In contrast, inflammation-related genes were upregulated in the liver and adipose tissue, although there was no significant effect with the GLP-1 analog treatments

Drugs are not metabolized by the liver, but multidrug and toxin extrusion protein 1 (MATE1) expressed in hepatocytes is involved in the clearance of drugs, which is transported to the kidney through bile or through blood (Gong et al., 2012)

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