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Furthermore, BHB influences adipocytes by upregulating uncoupling protein 1 (UCP1) and PR domain containing 16 (PRDM16) via the AMP-activated protein kinase(AMPK)/SIRT1/PGC-1 pathway, resulting in reductions in body weight and lipid levels [112]

In addition, KG is a cofactor for the Fe(II)/2-oxoglutarate-dependent dioxygenases (OGDD), including Jumonji-domain (JMJC)-containing histone demethylases, ten-eleven translocation (TET) DNA demethylases and hypoxia-inducible factors (HIF)-prolyl hydroxylases (PHD) essential for HIF-hydroxylation and consequent degradation [70]

Important Considerations Regulatory status: AOD-9604 is not FDA-approved

Nevertheless, challenging issues remain to be solved, such as poor encapsulation efficiency and the interference form exosomal endogenous nucleic acids and proteins