For individuals with a mild deficiency, it may take two to three shots over several days or weeks before they begin to feel a difference
Diagnostic aspiration or therapeutic injection of the ankle or first metatarsophalangeal joints can be performed for management of advanced osteoarthritis, rheumatoid arthritis, and other inflammatory arthritides such as gout, or synovitis or an arthrosis such as turf toe. Persistent pain and disability resulting from tarsal tunnel syndrome, an analog of carpal tunnel syndrome of the wrist, respond to local injection therapy
Meechan DW, Maynard TM, Wu Y, Gopalakrishna D, Lieberman JA, LaMantia AS
Normalization was carried out to account for technical variation, and keratins identified in blank Schirmer strip controls were removed, as previously published 30