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If you have known MTHFR mutations, a history of poor response to cyanocobalamin, or strong preference for methylcobalamin, seeking a formulation with that form is reasonable

Brian Holt, a Fellow of the American Society for Metabolic and Bariatric Surgery, reviews each patients levels before recommending a schedule

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Figure 4: Changes in body weight in A) lean mice and B) obese mice and changes in food intake in C) lean mice and D) obese mice, across the three different experimental treatment groups