Expanded approvals : Trials are ongoing for fatty liver disease, cardiovascular prevention in non-diabetics, and neurodegenerative disorders
In people with both type 2 diabetes and obesity, an indirect comparison drawing on the separate SURMOUNT-2 (NCT04657003) and STEP 2 (NCT03552757) trials, rather than a single head-to-head study, reported weight reduction of up to 15.7% with tirzepatide and 10.6% with semaglutide 2.4 mg
Get enough protein, especially from sources rich in the amino acid cysteine (like eggs, lean meats, and legumes)
Data analysed by paired two-tailed Students t-test ( j - m ), unpaired two-tailed Students t-test ( p and r ), one-way ANOVA, multiple comparison, Bonferroni post hoc test ( h ) and two-way repeated measures ANOVA to assess main effects of treatment ( c , d and s - v )