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Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides

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All had type 2 diabetes with an A1C level between 6.5% and 10.0%, meaning elevated blood glucose (blood sugar), and had either known atherosclerotic cardiovascular disease, a form of heart disease caused by plaque buildup in the arteries, chronic kidney disease, or both

Semaglutide FDA-approved uses for each brand are Ozempic (type 2 diabetes, reducing cardiovascular event risks, reducing risk of kidney function decline), Wegovy (weight management, reducing cardiovascular event risks, non-cirrhotic MASH), and Rybelsus (type 2 diabetes, reducing cardiovascular event risks)