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Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

In patients who already produce normal or elevated levels of endogenous GLP-1, flooding those same receptors with long-acting agonists may push a finely tuned system past its adaptive range

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Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and fatty acid biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence