Important cautions shared across this drug class: Thyroid C-cell tumours in rodents: long-acting incretin drugs carry a rodent finding that leads to caution in people with a personal/family history of medullary thyroid carcinoma (MTC) or MEN2
Adzynma, a purified recombinant form of this enzyme, provides a replacement for the low levels of the deficient enzyme in patients with cTTP
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The biological activities of glucosinolate derivatives, isothiocyanates and indole-3-carbinol, which include modulation of xenobiotic metabolism, but also antioxidant and anti-inflammatory properties, induction of cell cycle arrest and apoptosis, and inhibition of angiogenesis, likely contribute to the potential benefits of cruciferous vegetables in the prevention of cancer (see the MIC articles on Isothiocyanates and Indole-3-Carbinol) (23)
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