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Your kidneys contain millions of tiny blood vessels that act as filtration units

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As of 2024, seven GLP-1RAs are approved by the US Food and Drug Administration for the treatment of type 2 diabetes [1]

The glucagon receptor component is the key differentiator: glucagon activation increases energy expenditure and promotes lipolysis, meaning the body is pushed toward burning stored fat at a rate that neither semaglutide nor tirzepatide can replicate through their respective mechanisms alone [1]