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A lack of B12 has been observed in some cases of depression, suggesting that adequate levels may reduce the risk of severe mood disorders

Raf 1 represses expression of the tight junction protein occludin via activation of the zinc-finger transcription factor slug

However, evidence from research studies suggests that GLP-1 analogs may also reduce gastric acid secretion, which can impair the conversion of dietary B12 into its absorbable form and decrease binding to intrinsic factor, both of which are necessary for proper absorption