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The meta-analyses did not show any significant finding, but some studies implied potential efficacy of exogenous melatonin on depression [64]

It is characterized by the accumulation of -synuclein (-Syn) in the central and peripheral autonomic nervous systems, which contributes to the gradual degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) of the midbrain (1)

In none of the cases reported previously had patch tests been performed with pure MAL, so the possibility of a combined sensitization had not been completely ruled out