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doi: 10.1186/s13048-019-0572-7 65 RochetteLLorinJZellerMGuillandJCLorgisLCottinYet al

Naotaifang formula attenuates OGD/R-induced inflammation and ferroptosis by regulating microglial M1/M2 polarization through BMP6/SMADs signaling pathway

Linkage analysis of affected families showed association with the long arm of chromosome 9, and haplotype analysis localized the gene to 9q22.3 between D9S197 and D9S1809.[75] Transforming growth factor beta-receptor 1 ( TGFBR1 ) was identified through next-generation sequencing as the gene responsible for MSSE

Unlike the gold-standard Levodopa, which primarily alleviates symptoms but paradoxically generates iatrogenic ROS through auto-oxidation (Scigliano et al., 1997), bilirubin acts as an endogenous disease-modifying agent that specifically neutralizes such oxidative burdens (Jayanti et al., 2021)