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As the evidence evolves, clinicians will likely continue monitoring how metabolic therapies reshape osteoarthritis care in the years ahead

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Your healthcare provider may recommend changes if: Blood sugar remains uncontrolled Weight loss goals require adjustment Side effects become difficult to tolerate Some patients continue both medications, while others reduce the metformin dose or switch therapies based on clinical response

Barriers and facilitators to real-world implementation of the Diabetes Prevention Program in large healthcare systems: Lifestyle coach perspectives