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No published study has tested this split approach directly, but the pharmacological logic holds: maximize both local concentration and systemic delivery

T cells from children with ASD had a different pattern of co-stimulatory and activation markers following in vitro stimulation, with significantly increased expression of CD137 (4-1BB) but lower expression of CD134 (OX40) and CD25 (IL-2 receptor) [111]

Infection can be avoided with appropriate aseptic precautions