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Clinical trials do not consistently demonstrate significant tolerance development during the study periods

More systemic side effects, such as weight gain and high blood pressure, may develop over days or weeks of continued use

But heres the real challenge: Employers must balance short-term costs with long-term benefits

Barkley also didn't share if he was overweight or obese before starting on the drug to live longer, but an obesity expert previously told Insider that obesity can be life-threatening and those with more excess weight, particularly those who are severely obese, have a shorter life expectancy on average