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Macrophages exposed to choline deficiency or ChoK inhibitors (MN58b or RMS932A) exhibit poor PC and sphingomyelin mitochondrial membrane composition, leading to defective mitochondrial ATP synthesis that boosts AMPK activation and mitophagy ( Figure 3 )

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FSP1/CoQ10 and its related antioxidant system The ferroptosis suppressor protein 1 (FSP1)/coenzyme Q10 (CoQ10) pathway is another efficient endogenous antioxidant system independent of GPX4/GSH system, that critically regulates cellular sensitivity toward ferroptosis

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