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Researchers could not address potential clustering effects that could happen at the clinical site level because of the nature of the study

Consequently, these toxin-based models do not fully recapitulate the human disease pathology and may therefore yield results that are not directly applicable to clinical settings (Potashkin et al., 2011)

After exploring the mechanism of action in diabetic fatty rats and obese mice, researchers rapidly moved on to show the same effect in humans