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Studies in colon cancer cell lines (HTC116, HT29, RKO) showed that prolonged curcumin exposure modifies methylation across multiple CpG sites

"These products will likely never go through an FDA approval process," he says

Altogether, these studies suggest that both melatonin and treatments aimed to remodulate circadian homeostasis hold promise not only in enhancing treatment efficacy and quality of life, but also in potentially counteracting immunosuppressive and pro-metastatic mechanisms driven by circadian disruption in BC patients