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This should prompt re-appraisal of the role of KG in physiology and disease via mechanisms other than the KG-dependent DNA and histone demethylases
Based on the evidence that heat-shock proteins (Hsps) can exert neuroprotective effects against oxidative stress-related injury and that nutritional antioxidants are able to upregulate Hsps in neurons, use of nutritional antioxidants such as carnitine/acetyl-L-carnitine has been advocated to counteract the oxidative stress-induced brain damage in Alzheimer's disease [67, 119]
ACC1 expression has been shown to be frequently upregulated in several tumor types 37 , and have reported the expression and/or activation of ACC2 to be inhibited in a variety of cancers 38
It is formulated with both forms of Q10 (bioidentical ubiquinone and bioactive ubiquinol from the market leader Kaneka) and acetyl-L-carnitine
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