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As such, the blockage of K + channels but not K ATP channels, including Kv, BK Ca , TASK-1 and SK4 could lead to an enhancement of insulin release in human islets ( ATP channels with the application of tolbutamide ( 2+ mediated by VGCCs after glucose stimulation, which is critical for insulin release, is declined in Trpm5 (/) pancreatic islets, making an impaired glucose tolerance ( + currents and the resulting reduction of both transient and sustained insulin secretion ( Compared to other ion channels, obviously, K ATP channel is more essential in modulating the insulin secretion and glucose homeostasis, possibly due to linking cellular metabolism to electrical activity

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In one embodiment, compound of formula- 13 is having purity of greater than 98% by HPLC

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