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Delta Sleep-Inducing Peptide Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide first identified for its role in regulating sleep architecture

Available from: Wax, B, et al

To identify IGF-1-mediated miRNA regulatory networks that cause temozolomide (TMZ) to be insensitive to glioblastoma multiforme treatment, on the basis of comprehensive analysis of multiple databases and in vitro experiments, Chen et al (104) confirmed that IGF-1 upregulated miR-513a-5p signaling reduced the sensitivity of glioma cells to TMZ by inhibiting the NEDD4L-inactivated Wnt/-catenin pathway

Although several agents have demonstrated compelling efficacy in preclinical studies, clinical outcomes for many candidates remain limited