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The lack of growth hormone receptor activation eliminates the concerning side effects associated with growth hormone therapy, and the peptides very short half-life prevents tissue accumulation
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Reports are mixed: others describe improved mood and motivation, so the pattern reads as individual variation rather than a consistent Dihexa effect
The resulting increase in intracellular NAD+ availability activates sirtuins particularly SIRT1, which regulates insulin sensitivity, gluconeogenesis, cholesterol synthesis, and fatty acid oxidation, and SIRT3, which governs mitochondrial antioxidant defences and energy metabolism
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